Tetracycline: The Rise of Pfizer

The history of tetracyclines, including the rise of Lederle-Cyanamid's Aureomycin and Pfizer's Terramycin.

☠️NONE OF THE INFORMATION IN THIS VIDEO SHOULD BE USED AS MEDICAL ADVICE OR OPINION. IT IS FOR GENERAL EDUCATION AND ENTERTAINMENT☠️

???? L I N K S ????
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????My favorite books https://docs.google.com/document/d/1wuG-8EiF2lMbFdEG-9k1qi1d1KZAdGK1o41o7SYed_k/edit?usp=sharing

???? P A T R O N S ????
Joanne K
Sal F.
Jim Clay Jr
Ansel K
Brandon K
Pranav M
Paul
Brendan P
Dane M
Kristoffer R
Jakub V
Joe B
Karly N
Mindi F
Drake W
Kathy K
Mike W
Hyeon-Seo
Jacob S.
Robin B
Robb W
Sarah B
Dontae W
Karen S
Michael R
Brian H
Jonathan G
Brian T
Waffles the Dog
Thelma S
Silverstar
Brian B
Michael G
Zoe C

SOURCES
The Miracle Cure by William Rosen
https://www.amazon.com/Miracle-Cure-Creation-Antibiotics-Medicine/dp/0525428100?&_encoding=UTF8&tag=corporis-20&linkCode=ur2&linkId=8c4b80078cd36c6e3dd313b4c3db2694&camp=1789&creative=9325

Actinomycetes: A Never-Ending Source of Bioactive Compounds—An Overview on Antibiotics Production (2021) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8143475/
Tetracycline antibiotics (2021) https://link.springer.com/content/pdf/10.1007/s40828-021-00138-x.pdf
Tetracycline, StatePearls (updated 2023) https://www.ncbi.nlm.nih.gov/books/NBK549905/

Antibiotic Discovery and Development (2012) http://cmdr.ubc.ca/bobh/wp-content/uploads/2017/01/BC-Schurek-2012.pdf
The Development of Third-Generation Tetracycline Antibiotics and New Perspectives (2021) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8707899/

PIONEER LEADERS IN PLANT PATHOLOGY: BENJAMIN MINGE DUGGAR (1982) https://www.annualreviews.org/doi/pdf/10.1146/annurev.py.20.090182.000341
Dr. Benjamin Duggar Dies at 84 (1956) https://timesmachine.nytimes.com/timesmachine/1956/09/11/84708966.html?pageNumber=35

AUREOMYCIN: A PRODUCT OF THE CONTINUING SEARCH FOR NEW ANTIBIOTICS by Duggar (1948) https://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1749-6632.2011.06254.x?casa_token=6iXyYOyDzDsAAAAA%3APTYWGc8C_sEfntboUBguIIShANSarGUeJAAjbREghxW-vlY9OxCeY2ef9PvZ2jh3g656aFwMXidmgCBf
Aureomycin, a New Antibiotic (1949) https://www.nature.com/articles/163159a0.pdf
Chloramphenicol fact sheet from Pfizer https://labeling.pfizer.com/ShowLabeling.aspx?id=14816
Public Policy: Antitrust & Antibiotics (1961) https://web.archive.org/web/20110205040226/http://www.time.com/time/magazine/article/0,9171,895666,00.html
U.S. vs Pfizer (1974) https://www.justice.gov/media/1235821/dl?inline
Tetracycline litigation https://en.wikipedia.org/wiki/Tetracycline_litigation
Casetext US vs Pfizer (1982) https://casetext.com/case/in-re-coordinated-pretrial-proceedings-etc-9

An annotated version of the script with sources in footnotes can be found here: https://www.patreon.com/posts/tetracyclines-of-93954403

IMAGES
Wellcome polio vaccine. Wellcome Collection. Source: Wellcome Collection.
Licence: Attribution 4.0 International (CC BY 4.0) https://wellcomecollection.org/works/qps38n3k/images?id=vrbvbens
View of Sanborn Field from the adjacent Bond Life Sciences Center on the University of Missouri campus by Lwtwb8 (CC BY-SA 3.0)
https://en.wikipedia.org/wiki/Sanborn_Field#/media/File:SanbornField.png
https://www.flickr.com/photos/boston_public_library/4899342506/in/photostream/
Rickettsia typhi by David H. Walker (UTMB), George Weinstock (BCM-HGSC)
https://www.hgsc.bcm.edu/rickettsia-typhi
Tetracycline HCl substance by Rillke Creative Commons Attribution-Share Alike 3.0 Unported
https://commons.wikimedia.org/wiki/File:Tetracycline-HCl_substance_photo.jpg
Streptomyces rimosus, Leibniz-Institut DSMZ. Creative Commons Attribution 4.0 International License. (CC-BY 4.0) https://bacdive.dsmz.de/strain/15515
Arthur M Sackler in his office. Smithsonian's Freer and Sackler Galleries. CC BY-SA 2.0 DEED
https://en.wikipedia.org/wiki/Arthur_M._Sackler#/media/File:Arthur_M._Sackler.jpg
Parke, Davis and Company, manufacturing chemists, Detroit, Michigan. Packaging pills in the finishing department https://www.loc.gov/resource/ds.14946/
Antimicrobial sensitivity testing of Staphylococcus aureus on MHA after over night incubation by Ajay Kumar Chaurasiya CC BY-SA 4.0 DEED https://commons.wikimedia.org/wiki/File:Antibiogram_of_Staphylococcus_aureus_on_MHA.jpg

VIDEOS
The antibiotics and terramycin https://wellcomecollection.org/works/m2raqspe
Age of Promise (1956) https://wellcomecollection.org/works/jkhgxzzj

⌛T I M E S T A M P S ⌛
0:00 Intro
0:46 Part 1: Pay Dirt
6:52 Part 2: From the Earth
12:20 The Lawsuit
14:52 Part 3: New Generations of Tetracyclines

???? C O N T A C T ????
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